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th cre female mice  (Jackson Laboratory)

 
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    Structured Review

    Jackson Laboratory th cre female mice
    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). <t>TH</t> <t>Cre+</t> females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.
    Th Cre Female Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/th cre female mice/product/Jackson Laboratory
    Average 86 stars, based on 1 article reviews
    th cre female mice - by Bioz Stars, 2026-05
    86/100 stars

    Images

    1) Product Images from "Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females"

    Article Title: Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females

    Journal: Endocrinology

    doi: 10.1210/endocr/bqag049

    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). TH Cre+ females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.
    Figure Legend Snippet: (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). TH Cre+ females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.

    Techniques Used: Knock-Out, Control, Expressing

    RNAscope images and quantification of Th -expressing cells in the preoptic area (mid-RP3V) of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice ( n = 5-6/group). (A) Representative images showing similarly high Th mRNA expression in both CON mice (left) and Kiss1 RP3V KO mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (B) Quantification of Th -positive cells in the RP3V confirmed no significant effect on Th cell counts in KO mice compared to controls.
    Figure Legend Snippet: RNAscope images and quantification of Th -expressing cells in the preoptic area (mid-RP3V) of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice ( n = 5-6/group). (A) Representative images showing similarly high Th mRNA expression in both CON mice (left) and Kiss1 RP3V KO mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (B) Quantification of Th -positive cells in the RP3V confirmed no significant effect on Th cell counts in KO mice compared to controls.

    Techniques Used: RNAscope, Expressing



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    th cre female mice  (Jackson Laboratory)
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    Jackson Laboratory th cre female mice
    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). <t>TH</t> <t>Cre+</t> females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.
    Th Cre Female Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    th cre  (Jackson Laboratory)
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    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). <t>TH</t> <t>Cre+</t> females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.
    Th Cre, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). <t>TH</t> <t>Cre+</t> females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.
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    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). <t>TH</t> <t>Cre+</t> females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.
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    Image Search Results


    (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). TH Cre+ females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.

    Journal: Endocrinology

    Article Title: Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females

    doi: 10.1210/endocr/bqag049

    Figure Lengend Snippet: (A) Breeding strategy to generate conditional Kiss1 knockout mice (Kiss1 RP3V KO). TH Cre+ females were crossed with Kiss fl/fl males and then backcrossed again to produce Kiss1 RP3V KOs and control littermates. Kiss1 RP3V KO mice have excision of Kiss1- exon 2 only in TH-expressing neurons. In all experiments, controls (CON) were TH Cre− /Kiss fl/fl females. (B-D). BaseScope images and quantification of Kiss1 -expressing cells in hypothalamic regions of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice. (B) Representative images showing high Kiss1 mRNA expression in CON mice (left) and significantly reduced Kiss1 signal in knockout mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (C) Quantification of Kiss1 -positive cells in the RP3V confirmed a significant reduction in knockout mice compared to controls (* P < .05). (D) Representative BaseScope images showing high Kiss1 mRNA expression in the ARC in both CON (left) and Kiss1 RP3V KO (right) mice. 3V: third ventricle. Scale bars: 100 µm. (E) Quantification of Kiss1 -positive cells in the ARC confirmed no significant difference between the groups.

    Article Snippet: TH CRE female mice (Jackson Labs; RRID:IMSR_JAX:008601) on a C57BL6N background were crossed with male mice homozygous for the floxed Kiss1 exon 2 allele (Kiss1 fl/fl ) ( ).

    Techniques: Knock-Out, Control, Expressing

    RNAscope images and quantification of Th -expressing cells in the preoptic area (mid-RP3V) of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice ( n = 5-6/group). (A) Representative images showing similarly high Th mRNA expression in both CON mice (left) and Kiss1 RP3V KO mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (B) Quantification of Th -positive cells in the RP3V confirmed no significant effect on Th cell counts in KO mice compared to controls.

    Journal: Endocrinology

    Article Title: Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females

    doi: 10.1210/endocr/bqag049

    Figure Lengend Snippet: RNAscope images and quantification of Th -expressing cells in the preoptic area (mid-RP3V) of adult CON (TH Cre− /Kiss fl/fl ) and Kiss1 RP3V KO female mice ( n = 5-6/group). (A) Representative images showing similarly high Th mRNA expression in both CON mice (left) and Kiss1 RP3V KO mice (right) in the RP3V. 3V: third ventricle. Scale bars: 100 µm. (B) Quantification of Th -positive cells in the RP3V confirmed no significant effect on Th cell counts in KO mice compared to controls.

    Article Snippet: TH CRE female mice (Jackson Labs; RRID:IMSR_JAX:008601) on a C57BL6N background were crossed with male mice homozygous for the floxed Kiss1 exon 2 allele (Kiss1 fl/fl ) ( ).

    Techniques: RNAscope, Expressing